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KMID : 0381219700020080065
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Journal of RIMSK
1970 Volume.2 No. 8 p.65 ~ p.71
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THE KIDNEY AND ERYTHROPOIESIS
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Abstract
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The existence of an erythropeiesis stimulating factor, erythropoietin, has been confirmed by a number of investigators. The evidence that the kidney is the primary site of production of erythropoietin is conclusive. Hypoxia and cobalt have been demonstrated to stimulate the release or production of erythropoietin in the isolated perfused kidney. Elevated plasma levels of erythropoietin have also been reported following renal artery constriction. Fisher reported that increased erythropoietin production in the isolated kidney in response to cobalt, testosterone or hypoxic blood is a direct effect of these stimuli on the kidney rather than a release of erythropoietin from injured and disintegrating cells. Kuratowska et al. have reported a factor from saline-perfused, isolated anoxic kidneys which engendered erythropoietic activity when added to normal serum. In a more recent report, the factor was stated to be present in the nuclear fraction of the kidney. It has been well established that the isolated kidneys release erythropoietin under hypoxic conditions, and that the erythropoietic factor released by kidneys requires the alpha-globulin from blood plasma for its activity, and that the renal factor is thermolabile before the interaction with alpha-globulin and is stabilized by alpha-globulin.
It has been considered that there may be corelation between renal insufficiency and erythropoiesis. Reports of the association of erythrocytosis with hydronephrosis or renal carcinoma are becoming more frequent. It is interesting to think about the fact that limited observations have again demonstrated the occasional efficacy of cobalt as a therapeutic adjunct in the management of the anemia of chronic renal disease.
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KEYWORD
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